Amyotrophic lateral sclerosis, or ALS, is a type of motor neurone disease that lacks a curative treatment. Efforts focusing on Stem Cell and ALS Research have yielded notable positive results. The disorder occurs due to neural deterioration and disruption of neural circuits. Motor neurone disease symptoms typically include muscle weakening, difficulty walking, gait instability, etc. As the condition progresses, it leads to motor neurone disease final stages symptoms, such as, difficulty in breathing, paralysis, speech deficits, etc., which cause an inability to perform daily activities. The worsening disorder affects pulmonary functions and leads to low survival. Stem cells can protect, repair, and regenerate neurons, resulting in the recovery of the functional loss. Therefore, stem cell and ALS research have gained momentum.